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Garcinia Cambogia - Lipid control

Avicenna water is the only water of its kind contains %100 natural Garcinia Cambogia. Over 1000 years old history of medicine perfected by AVICENNA the prince of physicians.
Super CitriMax is the trade name for HCA from the dried fruit Garcinia Cambogia Which are the key ingredients in Avicenna. Did you know? FAN-T, Inc. Is the only beverage company in the world Make Avicenna by World renowned scientist directly?
* Patented Calcium/Potassium HCA Weight Control Ingredient* * Clinically Proven to Burn Fat and Reduce Caloric Intake by 25% * Soluble in Water and Highly Bioavailable * Heat Stable as well as Tasteless, Odorless and Colorless in Solution * Not a Central Nervous Stimulant—GRAS Affirmed
PATENTED, 100% NATURAL Super CitriMax® is a unique, highly soluble form of (–)-hydroxycitric acid (HCA) bound to the essential
minerals calcium and potassium.* Super CitriMax is extracted from the dried fruit of Garcinia cambogia (the
richest known source of HCA in nature, typically 10-30% by weight), then standardized to 60% HCA. Native
to Southeast Asia, the dried fruit has been used for centuries to make meals more “filling.” Super CitriMax is
100% natural, soluble in solution, highly bioavailable and clinically proven to reduce body weight without
stimulating the central nervous system.
SAFE AND EFFECTIVE Super CitriMax is the only GRAS (Generally Recognized As Safe)-affirmed weight management ingredient
clinically proven to burn fat and to reduce caloric intake by 25%. Low dosages of Super CitriMax taken in
beverages for two weeks have been shown to sustain satiety and reduce energy (calorie) intake, leading to
reduced body weight. Clinical studies have also shown that, over an eight-week period, people taking
clinical strength dosages of Super CitriMax plus diet and exercise lost 3-times more body weight than
people on diet and exercise alone.
Super CitriMax applications · Super CitriMax is highly stable in different processing conditions, including carbonation, coldfill and
high-temperature processes such as hotfill, UHT, retorting and extrusion.
beverages. · Super CitriMax is rapidly absorbed, reaching peak concentrations in 1-2 hours and with detectable
concentrations up to nine hours.
These distinctive product characteristics allow manufacturers to formulate innovative, value-added foods
and beverages and uniquely position them based on scientific findings and consumer trends.
PRODUCT CLAIMS Promotes Satiety to Help Consumers Eat Less Reduces Caloric/Energy Intake· Curbs Appetite and Reduces Food Intake· Inhibits Fat Production & Deposition Promotes Fat Burning Reduces Body Weight Super CitriMax® is the only all-natural HCA weight-management ingredient that is GRAS affirmed and clinically proven to help consumers eat fewer calories and burn more fat. Backed by extensive, peer-reviewed scientific research, it is proven safe and effective for use as a functional ingredient in innovative, value-added and consumer-friendly beverage products positioned for weight management and a healthy lifestyle like Avicenna™.
Here are some scientific studies supports the safety and efficacy of the ingredient in Avicenna: (-)HCA:
J Med. 2004;35(1-6):33-48.
Links
An overview of the safety and efficacy of a novel, natural(-)-hydroxycitric acid extract (HCA-SX) for weight management.
Preuss
HG, Rao
CV, Garis
R, Bramble
JD, Ohia
SE, Bagchi
M, Bagchi
D.
Department of Physiology, Medicine and Pathology Georgetown University Medical Center, Washington, DC 20057, USA. Garcinia cambogia-derived (-)-hydroxycitric acid (HCA) is a safe, natural supplement for weight management. HCA is a competitive inhibitor of ATP citrate lyase, a key enzyme which facilitates the synthesis of fatty acids, cholesterol and triglycerides. Previous studies in our laboratories have demonstrated the superior bioavailability of a novel calcium-potassium salt of HCA derived from Garcinia cambogia (HCA-SX, Super CitriMax). Greater bioavailability of HCA-SX was observed when taken on an empty stomach. HCA-SX was also shown to exhibit concentration-dependent release of serotonin in isolated rat brain cortex, which may explain its appetite suppressive action. Acute oral, acute dermal, primary dermal irritation, primary eye irritation and 90-day chronic toxicity studies, as well as Ames bacterial reverse mutation and mouse lymphoma tests, were assessed to determine the safety of HCA-SX. In the 90-day toxicity study, dose- and time-dependent effects of HCA-SX were assessed on body weight, selected organ weights, hepatic and testicular lipid peroxidation and DNA fragmentation, hematology and clinical chemistry, and histopathology in male and female Sprague-Dawley rats. No remarkable toxicity results were detected, demonstrating the safety of HCA-SX. Furthermore, clinical studies to evaluate the safety and efficacy of HCA-SX over a period of eight weeks were conducted in 60 human volunteers. Subjects were given a 2,000 kcal diet/day, participated in a 30 min walking exercise program 5 days/week and given an oral dose of placebo or 4666.7 mg HCA-SX (providing 2,800 mg HCA) in three equally divided doses 30-60 min before meals, Body weight, BMI, lipid profiles, serum leptin, serotonin and excretion of urinary fat metabolites were determined at 0, 4 and 8 weeks of treatment. At the end of 8 weeks, body weight and BMI decreased by 5.4% and 5.2%, respectively. Food intake, total cholesterol, LDL, triglycerides and serum leptin levels were significantly reduced, while HDL and serotonin levels and excretion of urinary fat metabolites (a biomarker of fat oxidation) significantly increased. No significant adverse effects were reported. These results demonstrate the safety, bioavailability and efficacy of HCA-SX in weight management.
Mol Cell Biochem. 2007 Oct;304(1-2):93-9. Epub 2007 May 15. Links
Super CitriMax (HCA-SX) attenuates increases in oxidative stress, inflammation, insulin resistance, and body weight in developing obese Zucker rats.
Asghar M, Monjok E, Kouamou G, Ohia SE, Bagchi D, Lokhandwala MF.
Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, USA. masghar@mail.uh.edu Super CitriMax (HCA-SX) is a novel calcium/potassium salt of (-)-hydroxycitric acid extracted from the dried fruit rind of the plant Garcinia cambogia, and commonly consumed as weight loss dietary supplement. In the present study, we investigated the effect of HCA-SX on inflammation, oxidative stress and insulin resistance in developing obese Zucker rats, an animal model of type II diabetes associated with inflammation and oxidative stress. Male Zucker rats (5-week old) were supplemented with vehicle (control) and HCA-SX in drinking water for 7 weeks. Oxidative stress markers, including malondialdehyde (MDA), protein carbonyl (DNPH), and protein tyrosine nitration (tyr-NO(2)) were measured in the liver and kidney tissues using biochemical and immunoblotting techniques. Compared to controls, the levels of MDA, DNPH and tyr-NO(2) were lower in the liver and kidney of HCA-SX-treated animals. Furthermore, the levels of C-reactive protein and interleukin-6, markers of inflammation measured by ELISA, were lower in the plasma of HCA-SX-supplemented animals compared to controls, as were levels of fasting plasma insulin, glucose, and triglycerides. Interestingly, insulin resistance did not develop in HCA-SX-supplemented rats. Food-intake and body weight gain was also lower in rats supplemented with HCA-SX compared to their control counterparts. These results suggest that HCA-SX supplementation in obese Zucker rats reduces food-intake, body weight gain, and also attenuates the increases in inflammation, oxidative stress, and insulin resistance observed in untreated animals. Therefore, HCA-SX may be used as an intervention to overcome obesity-related complications, including inflammation, oxidative stress, and insulin resistance.
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